Systematic review with meta-analysis of partial enteral nutrition for maintenance of remission in Crohn’s disease

2020 
Abstract Although enteral nutrition (EN) is effective for induction therapy in Crohn’s disease (CD), it remains unclear whether partial enteral nutrition (PEN), i.e., EN along with a daily diet, is effective for maintenance therapy in CD. It was hypothesized that PEN would be effective as a maintenance therapy in CD. This meta-analysis aimed to evaluate the efficacy and safety of PEN for maintenance therapy in CD. PubMed, EMBASE, Web of Science, and Cochrane Library were searched up to January 2019 for eligible prospective controlled trials, and then a meta-analysis was conducted. The primary outcome was clinical relapse, as defined in the primary studies. Eight studies with 429 patients were included in the meta-analysis. The rate of clinical relapse at 0.5-2 years was significantly lower in patients receiving PEN (420 to 1800 kcal/d) than in those not receiving nutrition therapy (RR: 0.67, 95% CI: 0.54-0.82, P
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