Synthesis and Antimicrobial Evaluation of Some New Pyrazolo[1,5-a]pyrimidine and Pyrazolo[1,5-c]triazine Derivatives Containing Sulfathiazole Moiety
2020
A number of important fused heterocyclic systems have been prepared by the reaction of 4-((3,5-diamino-1 H -pyrazol-4-yl)-diazenyl)- N -(thiazol-2-yl)-benzenesulfonamide with some bifunctional nucleophiles such as ethyl acetoacetate, acetylacetone or arylidenemalonononitrile derivatives to obtain pyrazolo[1,5- a ]pyrimidine derivatives. The structures of the newly synthesized compounds were determined based on their IR, 1 H and 13 C NMR and mass spectroscopic data. Most of the compounds produced showed good antibacterial and antifungal activity.
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