Evaluation of HER2/neu gene amplification in patients with invasive breast carcinoma. Comparison of in situ hybridization methods.

proto-oncogene amplification or HER2 pro-tein overexpression. HER2 amplification/overexpres-sion is associated with a more aggressive disease course,greater likelihood of recurrence and generally poorprognosis.The authors compared the specificity, simplicity of agiven procedure and method standardization, the sim-plicity of evaluation the results of each