Metabolism of diludine in experimental animals

A study of the biotransformation of diludine is valuable for the complete pharmacological and toxicological evaluation of the drug. The authors present the results of a study of the qualitative and quantitative composition of its metabolites in rats and rabbits. /sup 14/C-labeled I was produced from (1,3-/sup 14/C)acetoacetic ester with an 80% yield. It is established that I is virtually entirely metabolized in the bodies of the experimental animals.