AMD1 mRNA employs ribosome stalling as a mechanism for molecular memory formation

Martina M. Yordanova,Gary Loughran,Alexander V. Zhdanov,Marco Mariotti,Stephen J. Kiniry,Patrick B. F. OConnor,Dmitry E. Andreev,Ioanna Tzani,Paul Saffert,Audrey M. Michel,Vadim N. Gladyshev,Dmitry B. Papkovsky,John F. Atkins,Pavel V. Baranov

AMD1 mRNA employs ribosome stalling as a mechanism for molecular memory formation

2018

Martina M. Yordanova
Gary Loughran
Alexander V. Zhdanov
Marco Mariotti
Stephen J. Kiniry
Patrick B. F. OConnor
Dmitry E. Andreev
Ioanna Tzani
Paul Saffert
Audrey M. Michel
Vadim N. Gladyshev
Dmitry B. Papkovsky
John F. Atkins
Pavel V. Baranov

A regulatory mechanism that limits the number of complete protein molecules that can be synthesized from a single mRNA molecule of the human AMD1 gene encoding adenosylmethionine decarboxylase 1.

Keywords:

Protein biosynthesis
Regulation of gene expression
Ribosome
Gene
Encoding (memory)
Molecular biology
Molecular memory
Adenosylmethionine decarboxylase
Biology
Messenger RNA
Coding region
Stop codon
Transcription (biology)
Chemistry
Untranslated region
Cell biology

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