Intratumoral genome diversity parallels progression and predicts outcome in pediatric cancer

Linda Holmquist Mengelbier,Jenny Karlsson,David Lindgren,Anders Valind,Henrik Lilljebjörn,Caroline Jansson,Daniel Bexell,Noémie Braekeveldt,Adam Ameur,Tord Jonson,Hanna Göransson Kultima,Anders Isaksson,Jurate Asmundsson,Rogier Versteeg,Marianne Rissler,Thoas Fioretos,Bengt Sandstedt,Anna Börjesson,Torbjörn Backman,Niklas Pal,Ingrid Øra,Markus Mayrhofer,David Gisselsson

Intratumoral genome diversity parallels progression and predicts outcome in pediatric cancer

2015

Phenotypic and genetic heterogeneity of cells within a tumour is thought to mediate treatment resistance and contribute to cancer progression. Here the authors show that genetic diversity in pediatric cancers is common after chemotherapy and can be quantified to predict survival.

Keywords:

Genetics
Genetic heterogeneity
Cancer
Genome
Genetic diversity
Phenotype
Medical genetics
Biology
pediatric cancer
Kidney cancer
Cohort
Chemotherapy

Correction
Source
Cite
Save
Machine Reading By IdeaReader

References

Citations