TAp63 induces senescence and suppresses tumorigenesis in vivo

TAp63, a splice variant of the p53 homologue p63, suppresses tumorigenesis in p53-null mice by mediating Ras oncogene-induced senescence. TAp63-mediated senescence is independent of p53, but requires p21Waf/Cip1 and Rb. TAp63 overrides Ras-driven transformation, while its loss accelerates Ras oncogenesis.