Otology/Neurotology Pirymethamine and HEX Gene Expression in Cholesteatoma

Results: Complete evaluations were available for 107 patients. Fibrous dysplasia (FD) of the temporal bones was identified in the majority (71%). Clinically significant hearing loss (.5/1/2/4 kHz PTA >20 dB HL) was identified in 30 ears (20%). A conductive loss (70%) was more frequent than a sensorineural loss (30%) and overall was primarily mild (70%). External auditory canal stenosis, epi-tympanic involvement, and internal auditory canal involvement based on CT were found to be rare potential contributors to overall hearing loss (n = 10 ears). While canal cholesteatoma can be a major complication, it was only identified in one patient.