Enantioselective Nucleophilic Substitution of a 6,6-Bicyclic Dienyl Acetate by Palladium-Chiral Phosphine Catalyst.

The enantioselective nucleophilic substitution of (±)-2β-acetoxy-4aβ-methyl-2,3,4,4a,5,6-hexahydronaphthalene with dimethyl malonate anion was performed in the presence of palladium-chiral ligand catalysts to give optically active 2-di(methoxycarbonyl)methyl-4a-methyl-2,3,4,4a,5,6-hexahydronaphthalenes.