The Monoclonal Antibody NEO-201 Enhances Natural Killer Cell Cytotoxicity Against Tumor Cells Through Blockade of the Inhibitory CEACAM5/CEACAM1 Immune Checkpoint Pathway

Massimo C. Fantini,Justin M. David,Christina M. Annunziata,Maria Pia Morelli,Phillip M. Arlen,Kwong Y. Tsang

The Monoclonal Antibody NEO-201 Enhances Natural Killer Cell Cytotoxicity Against Tumor Cells Through Blockade of the Inhibitory CEACAM5/CEACAM1 Immune Checkpoint Pathway

2020

Massimo C. Fantini
Justin M. David
Christina M. Annunziata
Maria Pia Morelli
Phillip M. Arlen
Kwong Y. Tsang

Background: Natural killer (NK) cells are essential to innate immunity and participate in cancer immune surveillance. Heterophilic interactions between carcinoembryonic antigen (CEA) on tumor cells...

Keywords:

Monoclonal antibody
Immunology
Carcinoembryonic antigen
Cancer
Cytotoxicity
Immune checkpoint
Natural killer cell
Immune system
Medicine
Innate immune system
Blockade

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