Sedentary behaviour is associated with worse cardiometabolic profiles in COPD patients, irrespective of moderate intensity physical activity

Background: People with COPD have reduced physical activity and increased cardiometabolic disease. Understanding the relationship between different types of inactivity and cardiometabolic impairment is important to design appropriate interventions Aim: To determine the effects of physical inactivity and sedentary behaviour on cardiometabolic profiles in COPD patients Methods: Stable COPD patients underwent actigraphy over 8 days. Physical inactivity was defined as Results: Metabolic syndrome was more common in high (SE 71%, CP 66%) than low sedentary groups (BB 20%, LM 0%, p=0.01). High sedentary patients had greater insulin resistance (HOMA2IR) (SE 2.2±1.0, CP 3.1±2.2, BB 1.5±0.7, LM 0.9±0.4, p=0.028) and lower HDL cholesterol (SE 1.7±0.5, CP 1.5±0.5, BB 2.2±1.0, LM 2.4±0.6, p=0.015). On univariate analysis, after adjustment for age and gender, sedentary behaviour determined HOMA2IR and HDL, independent of physical activity Conclusions: Sedentary behaviour was associated with worse cardiometabolic profile, independent of physical activity. Interventions to promote non-sedentary behaviour could improve cardiometabolic profiles, even in COPD patients unable to achieve moderate intensity activity