Clinical implication and viral mutation in basal core promoter/pre-core of hepatitis B virus C/D recombinant

Background and aim Hepatitis B virus (HBV) C/D recombinant is predominant in Tibet in Western China. Although the geographical and ethnic distributions of the C/D recombinant have been described, the clinical implication and the characteristics of viral mutation in the basal core promoter (BCP)/pre-core (PC) region remain unclear.