CorrigendumCorrigendum to “Analysis of the variation in use-dependent inactivation of high-threshold tetrodotoxin-resistant sodium currents recorded from rat sensory neurons”: [Neuroscience 143 (2006) 923–938]

On page 931, Fig. 6, in the Tripathi et al. (2006) study, there was a glitch in the pClamp 8 protocol used to acquire data on inactivation from the closed state of high-threshold tetrodotoxin-resistant Na currents recorded from acutely isolated rat DRG cells. The glitch made it appear as if there was a fast phase of inactivation, which was complete before the first time point of 5 ms included in the protocol. Subsequent experiments with a revised data acquisition protocol demonstrated that no inactivation from the closed state occurred over the first 5 ms at 50 mV, and that overall inactivation was well fitted with a single exponential function. This new information was used to correct the data presented in the results and in Fig. 6 on inactivation from the closed state in the Tripathi et al. (2006) study. The correction method was to subtract out the artifactual inactivation corresponding to the 5 ms time point from that observed at the other time points. The resulting corrected Fig. 6 is presented below. For the corrected data, the time constant for inactivation from the closed state averaged 2667 827 ms, and there was a significant correlation between the amount of inactivation from the closed state observed after 10 s, and use-dependent inactivation (see part D below). Other data acquired in the Tripathi et al. (2006) study indicated that the high threshold tetrodotoxin-resistant Na channels expressed by individual DRG cells were homogeneous regarding inactivation properties regardless of the amount of use-dependent inactivation exhibited (see Fig. 2, Tripathi et al., 2006). Thus, we believe that the method of correction employed is reasonably accurate. The correct Fig. 6 appears here. (Available online 12 May 2011)