Erythrocyte Band 3 Protein Phosphorylation Modulates Anion Transport in Nephrolithiasic Patients

Higher oxalate1, and urate2 transmembrane self-exchange rates, and a faster endogenous phosphorylation of band 3 protein3, the anion carrier, were found in red cells from idiopathic calcium-oxalate renal stone formers. That these two cellular-abnormalities might be linked is an attractive hypothesis, but it is still debated whether anion transport modulation involves the phosphorylation of band 3 and other membrane proteins. To investigate this problem further, we studied the effect of agents known to interfere with membrane protein phosphorylation on anion transport.