Context-Dependent Transformation of Adult Pancreatic Cells by Oncogenic K-Ras

Sharon Y. Gidekel Friedlander,1 Gerald C. Chu,4,5,6 Eric L. Snyder,1,5 Nomeda Girnius,1 Gregory Dibelius,1 Denise Crowley,1,3 Eliza Vasile,1 Ronald A. DePinho,4,6,7 and Tyler Jacks1,2,3,* 1The David H. Koch Institute for Integrative Cancer Research 2Department of Biology 3Howard Hughes Medical Institute Massachusetts Institute of Technology, Cambridge, MA 02139, USA 4Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA 5Department of Pathology, Brigham and Woman’s Hospital, Boston, MA 02115, USA 6Center for Applied Cancer Science, Belfer Foundation Institute for Innovative Cancer Science, Boston, MA 02115, USA 7Department of Medicine and Genetics, Harvard Medical School, Boston, MA 02115, USA *Correspondence: tjacks@mit.edu DOI 10.1016/j.ccr.2009.09.027