Cellular prion protein regulates -secretase cleavage of the Alzheimer's amyloid precursor protein

*Proteolysis Research Group, Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, and †Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds LS2 9JT, United Kingdom; §Neurodegeneration Research, Neurology and Gastrointestinal Centre of Excellence for Drug Discovery, GlaxoSmithKline Research and Development Limited, Third Avenue, Harlow, Essex CM19 5AW, United Kingdom; ¶Mayo Clinic, Jacksonville, FL 32224; and Roslin Institute, Neuropathogenesis Unit, Edinburgh EH9 3JF, United Kingdom