Synthesis of Optically Active α-(Imidazol-1-yl, Purin-9-yl or Uracil-1-yl) Propanoic and Succinic Acid Derivatives.
1994
Abstract An efficient route is reported to chiral propanoic and succinic acid derivatives substituted in the α-position with adenine, hypoxanthine and uracil groups. These nucleic acid base derivatives are obtained in optically pure form by a procedure which starts from an amino acid as a convenient chiral synthon.
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