Interferência do diabetes mellitus tipo I nos níveis de lactose na transição entre as fases I e II da lactogênese em mulheres puérperas

A lactogenese e constituida por duas fases, designadas como I e II. Uma das caracteristicas da transicao entre estas fases e o aumento da concentracao de lactose no colostro. Este estudo teve como objetivo avaliar a interferencia do diabetes mellitus na transicao da lactogenese I para a lactogenese II. Foram avaliadas 11 mulheres puerperas portadoras de diabetes mellitus tipo 1 pre-gestacional e 19 puerperas sem diabetes. Nos cinco primeiros dias apos o parto, a cada intervalo de 24 horas, foram coletadas amostras do colostro das maes para analise de seu teor em lactose, por reacao com acido picrico. Em ambos os grupos houve um aumento progressivo na concentracao de lactose com o tempo. A dependencia da concentracao de lactose com o tempo, apos o parto, foi ajustada a uma curva de crescimento sigmoidal que mostrou a transicao da lactogenese I para a lactogenese II. A analise desta transicao revelou um atraso de 18 horas para inicio da lactogenese II nas puerperas portadoras de diabetes mellitus com controle metabolico inadequado em relacao as puerperas sem diabetes.%%%%Lactogenesis is constituted by two phases, called as lactogenesis I and lactogenesis II. The transition between those phases is characterized by increase in the lactose concentration. This study aimed to evaluate the interference of diabetes mellitus in the lactose concentration associated to transition between phases I and II of lactogenesis. It was studied 11 puerperal women with pre-gestational diabetes mellitus and 19 without diabetes. During the five first days after delivery, at each 24 hours, it was collected colostrums samples to evaluate its lactose concentration by reaction with picric acid. In both groups there were progressive increases in the lactose levels with time. The lactose concentrations in both groups exhibited statistically significant sigmoidal dependences with the time after delivery, with neat two-state transition between the phases I and II of lactogenesis. The analysis of those transitions revealed an 18 hours time delay in the beginning of lactogenesis II of diabetes carriers women with inadequate metabolic control in relation to puerperal females without diabetes.