Controlling Lipid Micelle Stability Using Oligonucleotide Headgroups

Lipid-based micelles provide an attractive option for therapeutic and diagnostic applications because of their small size ( 24 h. Using antisense oligonucleotides we demonstrated that disruption of the quadruplex leads to micelle destabilization and cargo release. The ability to use oligonucleotide interactions to control lipid particle stability represents a new approach...