THE CHANGES OF PLASMA CONCENTRATION OF IL-13 AND IL-15 IN CHILDREN WITH HENOCH-SCHOENLEIN PURPURA AND THEIR SIGNIFICANCE

Objective To investigate the changes of interleukin-13(IL-13) and interleukin-15(IL-15) in children with Henoch-Schoenlein purpura(HSP) and discuss the related clinical significance.Methods Plasma levels of IL-13 and IL-15 were detected by ELISA in 61 children with HSP in acute phase and 25 normal children.The level of IL-13 and IL-15 of HSP children in different clinical categories were compared.Results IL-13 level in children with HSP in acute phase was significantly higher than that of healthy controls(t′=-5.49,P0.01);IL-13 level of HSP children with or without renal involvement was significantly higher than that of healthy controls(F=53.92,q=13.87,3.40;P0.01 or 0.05),those with renal involvement was significantly higher than that without renal involvement(F=53.92;q=11.86,P0.01).IL-15 level of children with HSP in acute phase was significantly higher than that of the controls(t′=8.98,P0.01);IL-15 level of children with HSP with or without renal involvement was significantly higher than that of healthy controls(F=40.45;q=12.18,3.46;P0.01);and those with renal involvement was significantly higher than that without(q=9.95,P0.01).Conclusion Significant increase in plasma IL-13 and IL-15 level of children with HSP in acute phase suggests that IL-13 and IL-15 play a crucial role in pathogenesis of HSP and correlate with nephritis of HSP.