Expression and singnificance of AQP-1 in lung tissue of rats with hypoxic pulmonary hypertension

Objective To study the expression and singnificance of AQP-1 in lung tissue of rats with hypoxic pulmonary hypertension.Methods 60 Wistar male rats which weight rang from 200 g to 280 g were divided into four groups:control group,altitude hypoxia environment 10 d,20 d,30 d group,measured the pulmonary artery pressure of each group and AQP-1 immunohistochemical staining in lung tissue,analysis the expression AQP-1 and the relationship with pulmonary artery pressur.Results The expression intensity of AQP-I and pulmonary artery pressure gradually increased with altitude hypoxia time extension,the expression of AQP-1 and the pulmonary artery pressure slowly increase with time extent.Conclusions AQP-1 and pulmonary artery pressure was positively correlated at the process of altitude hypoxia environment pulmonary hypertension,AQP-1 may play an important role in the development of pulmonary hypertension of hypoxia environment,by regulating the expression of AQP-1 may prevent pulmonary hypertension. Key words: Rats ;  Aquaporin-1 ;  Hypoxic pulmonary hypertension