Abstract PO-097: Treatment-related toxicities in Black and White women taking adjuvant endocrine therapy

Purpose: The effectiveness of adjuvant endocrine therapy (AET) to reduce morbidity and mortality among women diagnosed with hormone-receptor positive (HR+) breast cancer (BC) is well understood, yet the potential debilitating toxicities for Black survivors is not. Further, symptom toxicities impact treatment adherence. Using a mixed methods approach, this study examined patterns of reported AET- related toxicities in HR+ Black and White survivors. Methods: Study participants were enrolled in the Women’s Hormonal Initiation and Persistence study, a longitudinal observational trial of women diagnosed with HR+ breast cancer. Data regarding patient (e.g. race), medication (e.g. AET type), cancer care delivery (e.g. communication), and clinicopathologic factors (e.g., chemotherapy) were collected via surveys and medical charts. The FACT-ES assessed AET toxicity at baseline, 12 and 24 months. Primary analyses focused on the first year; secondary analyses explored changes over time. Multivariable linear regression models examined predictors of AET overall toxicity and for 5 toxicity subgroups. Focus groups with women (N=30) prescribed AET were transcribed verbatim, coded and analyzed. Results: Of the 570 participants, 28% were Black. Black women were more likely to have chemotherapy prior to starting AET but as likely as whites to have radiation. Most women (62%) were taking aromatase inhibitors (AIs). In unadjusted analyses Black women reported more overall, vasomotor, neurological, and gastrointestinal toxicities (p Citation Format: Vanessa B. Sheppard, Arnethea L. Sutton, Reuben Retnam, Kandace P. McGuire. Treatment-related toxicities in Black and White women taking adjuvant endocrine therapy [abstract]. In: Proceedings of the AACR Virtual Conference: Thirteenth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2020 Oct 2-4. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(12 Suppl):Abstract nr PO-097.