Regulation of Lipid Metabolism by Palmitoleate and Eicosapentaenoic Acid (EPA) in Mice Fed a High-Fat Diet

We investigated whether oral administration of palmitoleate ameliorates disorders of lipid metabolism to clarify the effects of one of the components of fish oil. Lipid levels in the liver and plasma were significantly decreased by palmitoleate and by EPA administration. These results suggest that palmitoleate, in addition to EPA, plays a role in the regulation of lipid metabolism by fish oil.