A Case Report of Adenomatoid Odontogenic Tumor Arising in a Pregnant Woman

Adenomatoid odontogenic tumors are uncommon odontogenic lesions of which biological features have not been fully understood. We report a case of adenomatoid odontogenic tumor arising in a pregnant woman. The patient was a 20-year-old Japanese female complained of a swelling in the right maxillary gingiva and the swelling rapidly enlarged in size after pregnancy. We investigated the lesion immunohistochemically to find out biological behavior. Bcl-2 protein was strongly positive, and growth activity determined by MIB-1 was extremely high. Immunoreactivity for estrogen receptor was not detected. These results suggest that this adenomatoid odontogenic tumor showed rapid growth due to high proliferative activity and also inhibition of apoptotic cell loss but not dependent on estrogen receptor in our case.