Response to Comment on Pellegrinelli et al. Human Adipocytes Induce Inflammation and Atrophy in Muscle Cells During Obesity. Diabetes 2015;64:3121–3134

We appreciate the comments by Moro and Bourlier (1) regarding our recent study (2), which shows the capacity of visceral fat–derived adipocytes from obese patients to promote inflammation and atrophy of muscle cells. Briefly, we identified interleukin (IL)-6 and IL-1β as drivers of the inflammatory burst of cocultured cells and a substantial amelioration of the atrophic phenotype by IGF-II/insulin growth factor binding protein-5. Given that our data do not support the direct role of IL-6 or IL-1β in promoting atrophy in muscle cells, we agree that further research is needed to …