Effects of dexmedetomidine on cerebral oxygen saturation and postoperative revival period in elderly patients with ovarian cancer

Objective To observe the effects of dexmedetomidine on cerebral oxygen saturation and postoperative recovery in elderly patients with ovarian cancer. Methods Sixty elderly patients with ovarian cancer were randomly divided into two groups. Both groups were given total intravenous anesthesia. Patients in group D were given a loading dosage of dexmedetomidine 0.5 μg/kg, followed by continuous infusion 0.2 μg·kg-1·h-1 until 30 minutes before the end of operation. Group C were given normal saline at the same time. The cerebral oxygen saturation was observed and recorded before anaesthesia (T0), an hour after operation (T1), the end of operation (T2) and 30 min after tracheal extubation (T3). The time of extubation and adverse reactions such as restlessness, shivering and respiratory inhibition were observed in both groups. Results There was no significant difference in cerebral oxygen saturation between the two groups at different time points (P>0.05), and the degree of restlessness and its incidence in group D were lower than those in group C, and the adverse reactions such as shivering were lower (P<0.05). Conclusion Dexmedetomidine has no obvious effect on cerebral oxygen saturation in elderly patients with ovarian cancer. It can effectively prevent and reduce postoperative restlessness, does not affect recovery time, and has fewer adverse reactions. Key words: Dexmedetomidine; Ovarian cancer; Cerebral oxygen saturation; Revival period