Alifanos, cyclophanes, heterafanos, heterofanos, hetero-substituted metallocenes heterafanos and useful for the treatment of HCV infections

1. A compound of Formula I: TR-J1-J1-RT -WAW; TR-J1-A-J1-RT; TR-J2-A-J2-RT; TR-J1-WA-J1-RT; TR-J1-W-5 A-J2-RT; or TR-J1-A-J2- RT or a pharmaceutically acceptable salt thereof; wherein: T is independently selected at each occurrence from T1 and T2; and T1 is -YZ, where Y is covalently bonded to R, and Y is a, C1-C4 alkylene linkage optionally substituted with oxo; and Z is a heterocyclic group of 5 or 6 members, each T1 substituted with (i) at least one substituent selected from - (C> = O) OH, - (C> = O) NH2, - (C> = O ) H, -C1-C4 alkyl, C2-C4 alkanoyl, C1-C4 alkyl, C1-C4 alquenilester, alkylcarboxamide mono- or di- C1-C4 and (ii) optionally substituted with one or more substituents independently selected from halogen, hydroxy , C1-C2 and C1-C2 alkoxy alkyl; T2 is independently selected at each occurrence from alkanoyl C2-C6, alkyl C1-C6, alquenilester C1-C6 alkylsulfonamide C1-C6 alkyl, C1-C6 alkyl, C2-C6 alkanoyl substituted with mono- or di-hidrocarbilcarbamato C1-C6 alkanoyl C2-C6 substituted urea or mono- or alkylurea C1-C6 alkanoyl and C2-C6 substituted mono- or C1-C6 dialkylcarboxamide, each T2 optionally substituted with 1 or more substituents independently selected from amino, cyano, hydroxyl, halogen, (C1-C4) C0-C4alkyl, (mono- and di-alkylamine C1- C4) C0-C4 alkyl, C1-C6 alkyl, (thioalkyl C1-C4) alkyl C0-C4 alkyl, C3-C7, phenyl, C1-C2 haloalkoxy and C1-C2; R is independently selected at each occurrence from rings 4 to 6 membered rings containing one or two nitrogen atoms being carbon atoms the remaining ring atoms, said R is saturated or contains one unsaturated bond and is optionally connected to a methylene or ethylene bridge, or fused to a phenyl or heteroaryl ring 5 to 6 members; and bicyclic ring systems fused or spiro 6 to 10 members containing one or two nitrogen atoms being carbon atoms the remaining ring atoms, said bicyclic ring 6 to 10 members is saturated or contains one unsaturated bond; each R is optionally substituted with one or more substituents independently selected from cyano, hydroxyl, halogen, C1-C2, C1-C2 alkoxy, C1-C2, C1-C2 haloalkyl C1-C2 and C1-C2; J1 is phenyl or a heteroaryl group of 5 to 6 members containing 1 to 3 heteroatoms independently selected from N, O and S, wherein each J1 is optionally substituted with one or more substituents independently selected from amino, cyano, hydroxyl, halogen, C1-C4alkyl, C1-C4alkoxy, mono- and di C1-C4 alkyl, C1-C2 haloalkoxy and C1-C2; J2 is a heteroaryl group of 8 to 10 members containing 1 to 4 heteroatoms independently selected from N, O and S, wherein J2 is optionally substituted with one or more substituents independently selected from amino, cyano, hydroxyl, halogen, C1-C4, C1-C4alkoxy, mono- and di C1-C4 alkyl, C1-C2 haloalkoxy and C1-C2; W is independently selected at each occurrence and is a phenyl, pyridyl or alkynyl, optionally substituted with one or more substituents independently selected from amino, cyano, hydroxyl, halogen, C1-C4alkyl, C1-C4alkoxy, mono- and di C1-C4 alkylamino, C1-C2 haloalkoxy and C1-C2; A is [jk] -ciclofano [jk] -hetera-Fano, [jk] tricycloalkenyl-Fano, [jk] tricycloalkenyl-hetera-Fano or [jk] -alifano; where j is an integer 1 to 4, k is an integer from 1 to 4, the difference between j and k is not greater than 2, and each jyk linker optionally containing one heteroatom selected from N, O and S, and optionally substituted with one oxo group, and one or more substituents independently selected from halogen, hydroxy, amino, C1-C2 and C1-C2 alkoxy alkyl; or A is a [jkj'.k '] - cyclophane, where j, j', k and k 'are integers from 1 to 4, the difference between numbers jykok' is not greater than 2, the difference between j 'ykok' is not greater than 2 and each linker j, j ', k and k' optionally contains a heteroatom selected from N, O and S, and is optionally substituted with one oxo group and one or more substituents independently selected from halogen, hydroxy, amino, C1- alkyl C2 and C1-C2 alkoxy; or A is a group of formula: ** ** Formula wherein Q is a neutral or cationic metal, each A being optionally substituted with one or more substituents independently selected from halogen, C1-C2 and C1-C2 alkoxy alkyl; or A is a group of formula: ** ** Formula A being optionally substituted with one or more substituents independently selected from halogen, C1-C2 and C1-C2 alkoxy alkyl.