SYNTHESIS AND BIOLOGICAL ACTIVITY OF SUBSTITUTED TETRACHLOROPHTHALIC ACID MONOAMIDES

A series of tetrachlorophthalic acid derivatives were obtained by acylating primary amines with tetrachlorophthalic anhydride under mild conditions. Antibacterial activity of the synthesized compounds with respect to Escherichia coli and Staphylococcus aureus was studied in vitro by the serial dilution technique. The most pronounced antimicrobial effect in the series of compounds tested was observed for 2-hydroxyphenylamide of tetrachlorophthalic acid; 4-antipyrylamide of tetrachlorophthalic acid showed a significant antiinflammatory activity.