Metahemoglobinemia. Causa de cianosis en el niño
2010
Title: Methemoglobinemia. Cause of cyanosis in the child The methemoglobin (MHb) is a form of hemoglobin which shows iron “hem” in ferric (oxidized), while minimizing its uptake and oxygen transport. Methemoglobinemia occurs when by the genetic cause the redox mechanisms are insufficient or if acquired by the amount of oxidizing substances which exceed the redox mechanism of red blood cells. We present two clinical cases, the first being an infant after prolonged exposure to an oxidizing substance (EMLA ® patch) presented with hemodynamic cyanosis, high levels of MHb and response to methylene blue. The second patient was a girl with cyanosis since birth in which there was a deficit of cytochrome b5 reductase. Before a cyanotic patient without infectious, respiratory and cardiovascular known cause and without a response to oxygen therapy it is necessary to exclude methemoglobinemia.
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