W1919 Psychological Stress in Early Life Leads to Abnormal Postprandial Ghrelin Profile and Early Satiety in Adulthood: Validation of a Rat Model for Functional Dyspepsia (FD)

G A A b st ra ct s rats is clearly evident in H&E-stained sections whereby villi height is lower and muscularis atrophy is evident. Conclusions: Our data indicate that SMA blood flow is compromised in rats after T3 SCI at a time when gastric emptying and motility are also reduced. Duodenal administration of a liquid meal was insufficient in triggering visceral hyperemia. We suggest that impaired systemic vascular flow diminishes compensatory mesenteric blood flow to support the GI tract during digestion. The resulting GI ischemia may be an underlying pathology leading to gastric dysfunction seen following SCI. Support: NINDS 049177