Synthesis and evaluation of spirobenzazepines as potent vasopressin receptor antagonists

Abstract A novel series of spirobenzazepines was synthesized and evaluated for V 1a and V 2 receptor antagonist activity. Compounds 8b , 8i , and 8k have shown selective V 1a receptor antagonist activity. Compounds 8p and 8q were shown to be dual V 1a /V 2 receptor antagonists.