Achievement of LDL-C goals depends on baseline LDL-C and choice and dose of statin: An analysis from the VOYAGER database:

BackgroundReducing low-density lipoprotein cholesterol (LDL-C) levels decreases cardiovascular risk in direct proportion to the decrease in LDL-C.DesignThe aim of this study was to assess the importance of baseline LDL-C and choice and dose of statin in achievement of LDL-C goals of 100 and 70 mg/dl, using a novel statistical model. The analysis included 30,102 patient exposures to rosuvastatin 10–40 mg or atorvastatin 10–80 mg from 31 direct comparative trials in the VOYAGER database.MethodsFor each statin dose, percentage goal achievement was plotted for 20 equally large subgroups defined by baseline LDL-C. Logistic regression analysis was then performed for each statin dose to estimate the percentage of patients reaching target. Best-fit logistic regression curves were plotted ‘pair-wise’, comparing each rosuvastatin dose with equal or higher doses of atorvastatin.ResultsLDL-C <100 mg/dl was achieved by 53.7–85.5% of patients on rosuvastatin 10–40 mg and 43.3–80.0% of those on atorvastatin 10–80 mg, wh...