Pellino3 ubiquitinates RIP2 and mediates Nod2-induced signaling and protective effects in colitis

The E3 ubiquitin ligases that modify the kinase RIP2 downstream of the receptor Nod2 remain unclear. Moynagh and colleagues show that Pellino3 ubiquitinates RIP2 for Nod2-induced activation of the transcription factor NF-κB.