1932-P: A Novel Antiobesity Peptide Secreted from Brown Adipocytes

Obesity, the most common metabolic disorder worldwide, is characterized by excess adipose tissue accumulation and causes to serious complications. Many studies have suggested that brown adipocytes contribute to weight loss with increased energy expenditure. Since white adipocytes could be convertible to a “brown-like” state, and induction of browning of white fat also become a promising strategy in the treatment of obesity. Notably, brown fat is not only a heat-producing but also a secretory organ communicating with other metabolic organs. In this study, we focused on peptides secreted by brown adipose tissue to discover new treatment against obesity and metabolic disorder. We successfully obtained a novel polypeptide from the secretory components of brown adipocytes named as BATSP1 (Brown Adipose Tissue Secreted Peptide), which played crucial role in stimulating browning of white adipocytes. The function and mechanism of BATSP1 were comprehensively evaluated in animal models, and we found that administration of BATSP1 stimulated browning of white adipose tissue and elevated mitochondria number dramatically consisting with the activation of energy metabolism. Moreover, to evaluate the feasibility of BATSP1 as a treatment for obesity, we treated DIO mice with BATSP1 and caused significant weight loss as well as decreased glucose and triglyceride content via browning. Taken together, we described an anti-obesity peptide secreted from brown adipocytes, and the underlying mechanism require further study to develop its clinic application. Disclosure Z. Zhang: None. X. Zhang: None. H. Zhong: None. X. Chi: None. X. Cui: None. C. Ji: None. Funding National Natural Science Foundation of China (81770866, 81770837, 81900783)