5-Amidinoindoles as Dual Inhibitors of Coagulation Factors IXa and Xa.

Douglas G. Batt,Jennifer X. Qiao,Dilip P. Modi,Gregory C. Houghton,Deborah A. Pierson,Karen A. Rossi,Joseph M. Luettgen,Robert M. Knabb,Prabhakar K. Jadhav,Ruth R. Wexler

5-Amidinoindoles as Dual Inhibitors of Coagulation Factors IXa and Xa.

2005

Douglas G. Batt
Jennifer X. Qiao
Dilip P. Modi
Gregory C. Houghton
Deborah A. Pierson
Karen A. Rossi
Joseph M. Luettgen
Robert M. Knabb
Prabhakar K. Jadhav
Ruth R. Wexler

Structural features of a 5-amidinoindole inhibitor of factor Xa, which displayed modest inhibition of factor IXa were varied to increase potency and improve selectivity for factor IXa.

Keywords:

Organic chemistry
Chemistry

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