A rheumatoid arthritis study by Fourier transform infrared spectroscopy
2012
Rheumatoid arthritis is a systemic inflammatory disease of unknown causes and a new methods to identify it in early
stages are needed. The main purpose of this work is the biochemical differentiation of sera between normal and RA
patients, through the establishment of a statistical method that can be appropriately used for serological analysis. The
human sera from 39 healthy donors and 39 rheumatics donors were collected and analyzed by Fourier Transform
Infrared Spectroscopy. The results show significant spectral variations with p<0.05 in regions corresponding to protein,
lipids and immunoglobulins. The technique of latex particles, coated with human IgG and monoclonal anti-CRP by
indirect agglutination known as FR and CRP, was performed to confirm possible false-negative results within the groups,
facilitating the statistical interpretation and validation of the technique.
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