Evaluation of pyrazolopyrimidine derivatives as microtubule affinity regulating kinase 4 inhibitors: Towards therapeutic management of Alzheimer’s disease

Ahmad Abu Turab Naqvi,Deeba Shamim Jairajpuri,Omar M. Noman,Afzal Hussain,Asimul Islam,Faizan Ahmad,Mohammed F. Alajmi,Md. Imtaiyaz Hassan

Evaluation of pyrazolopyrimidine derivatives as microtubule affinity regulating kinase 4 inhibitors: Towards therapeutic management of Alzheimer’s disease

2019

Ahmad Abu Turab Naqvi
Deeba Shamim Jairajpuri
Omar M. Noman
Afzal Hussain
Asimul Islam
Faizan Ahmad
Mohammed F. Alajmi
Md. Imtaiyaz Hassan

AbstractMicrotubule affinity regulating kinase 4 (MARK4) plays essential role in the tau-assisted regulation of microtubule dynamics. Over expression of MARK4 causes early phosphoryalation of Ser26...

Keywords:

Kinase
Pyrazolopyrimidine
Biochemistry
Microtubule
Microtubule dynamics
Docking (molecular)
Chemistry
Ligand (biochemistry)
In silico
Hyperphosphorylation
Cell biology
Tau protein

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