Hemoglobin nano-particle and preparation method thereof

The invention discloses a method for preparing a hemoglobin nano-particle for transferring pharmacological active compounds. The method comprises the following steps: dissolving hemoglobin in a solvent; adding acid, alkali or positive and negative charge polyelectrolyte, and a denaturing agent; and coating the pharmacological active compounds inside to form the hemoglobin nano-particle. According to the method, the encapsulation efficiency of the nano-particle is over 80 percent, and is superior to the prior art, so that a high-efficiency low-consumption method is formed; and furthermore, the drug loading capacity up to 60 percent can be obtained by the method, which means that the nano-particle contains 60 percent of the pharmacological active compounds. Due to higher drug loading capacity, a smaller administration volume and shorter administration time can be obtained in treatment, and patients feel more convenient; due to high drug loading capacity, the usage of protein is reduced when pharmacological active components are transferred, the product finished production efficiency can be improved, but the administration volume is not limited.