Endurance running program reverses the age related declines in peak oxygen consumption

1986 
This study was designed to determine whether aging per se produces a decline in peak oxygen consumption (peak VO/sub 2/) or whether that decline may be due to the documented reduction in spontaneous activity. Male F344 rats, at the initial ages of 4 and 18 mos. of age, were divided into trained and untrained groups (YUT, YT, OUT, and OT). The trained groups ran up to 60 min/day 5 days/wk at a speed of 20m/min for 6 mos. The OUT rats demonstrated a 12% decline in peak VO/sub 2/ when compared to YUT rats. The OT rats had the same peak VO/sub 2/ as the YUT, but a 13% lower peak VO/sub 2/ than the YT. Representative enzymes of the TCA cycle, B oxidation, and electron transport system from gastrocnemius homogenates all declined in the OUT compared to YUT (14 to 24%). /sup 14/C-palmitate oxidation declined 45% in the OUT gastrocnemius compared to YUT. The carnitine values of the OUT were not significantly lower than the YUT and could not account for the large depression in palmitate oxidation. In contrast to the peak VO/sub 2/ which increased in OT only up to YUT values, the oxidative capacity of the skeletalmore » muscle of OT was increased above the YUT group values equal to those of YT.« less
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