Regio-selective preparation of vinyl adenosine ester catalyzed by alkaline protease

The transesterification of divinyladipate with adenosine in DMF containing 20% (v/v) DMSO was catalyzed by Streptomyces sp. alkaline protease and esterification occurred exclusively at the 3′-position of hydroxyl group of ribofuranose in adenosine to give 3′-O-vinyladipoyl adenosine without other products.