Mcam modulation and uses thereof in the management of neuroinflammatory conditions

Methods, uses, agents and compositions useful for the prevention, treatment and/or diagnosis of inflammatory conditions, including neuroinflammatory conditions such as multiple sclerosis and spinal cord injury based on the modulation of nerve injury-induced protein-1 (Ninjurin-1) and/or melanoma cell adhesion molecule (MCAM) are disclosed. Methods, and kits useful for the identification and selection of inflammatory cytokine-secreting T cells or precursors thereof, are also disclosed.