Milbemycins analogues as well as preparation method and application thereof in pesticides

The invention discloses milbemycins analogues as well as a preparation method and application thereof in pesticides. The new milbemycins analogues have the following structural formula shown the specification, wherein R1 is 2-naphthyl, p-methylphenyl, methyl, 2,4-difluorophenyl or p-chlorphenyl; and R2 is p-methoxyphenyl, p-methylphenyl or phenyl. The analogues have equivalent or higher contact toxicity on Tetrangychus cinnabarinus and Aphis craccivora compared with ivermectin, so the analogues can be used for preventing and controlling the agricultural pests (mites).