Response to "Standardised methods must be used to compare the properties of botulinum toxin serotypes"
2017
First, we would like to provide some further explanation of the potency assay. We used two types of potency assay because the BoNT subtype B6 (BoNT/B6) was purified from strain Osaka05, which was isolated relatively recently (1). To compare the potency of BoNT/B6 with each of the subtypes reported previously, we first investigated its potency in mice using an intraperitoneal bioassay. Based on the results of this assay, we used an intravenous time-to-death mouse bioassay to construct a standard curve for BoNT/B6.
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