PERBEDAAN KADAR SGOT, SGPT DAN GAMMA GT PADA PASIEN TALASEMIA BETA MAYOR DENGAN KELASI BESI DEFERASIROX DAN DEFERIPRONE

Background: Iron accumulation in liver in patient with major thalassemia which has already having repeated transfution could cause liver disfuntion. Iron chelation is understood to be needed to reduce the dysfunction of the liver. Objective: This study aim is to know whether there is differences in ALT/AST and Gamma GT level in mayor thalassemia patient with deferiprone and deferasirox chelation therapy Methods:This study was analytical study with cross sectional study with examination of ALT/AST and Gamma GT levels in deferiprone and defersirox groups which met the inclusion and exclusion criteria. Differences in enzyme levels were compared between the two groups then analyzed with the Mann - Whitney test . Result: There was a siginificantly difference between two groups in Gamma GT level, which is in the mean of 24,5 ± 14,08 u/l in the deferiprone group and mean 16,78 ± 6,81 u/l in deferasirox group with p = 0.011. however, the ALT and AST level were decreased in deferasirox group compared to deferiprone group although it was not statisticaly significant (p=0,142 dan p=0,122) Conclusion: There is a siginificant difference in Gamma GT level in deferasirox group compared to the deferiprone group. The ALT and AST level in deferasirox group is lower than the other group although it was not statisticaly significant. Deferasirox is considered to be more effective in decreasing the dysfunction of liver function. Keywords: Major Thalassemia, Chelation, SGOT, SGPT, GAMMA GT