Urinary RBP and glucocorticoid hormone therapy sensibility in adult primary nephrotic syndrome

Objective To clarify the relationship between the renal tubular funciton and the efficacy of glucocorticoid, in adult patients with primary nephrotic syndrome. Methods Pro and post therapy urinary RBP and NAG were determined double antibodies sandwich ELISA and color comparimetry with p nitrate reductase, respectively. in eighty adult patients with primary nephritic syndrome, according to the concentrations of urinary protein, these patients were divided into three no remission group, partial remission group and fully remission group, fifty one normal persons as control group. Renal tubular function parameters among groups were compared before and after therapy, and the results were analysed when those parameters were used to predict the sensibility of glucocorticoid therapy. Results ①There were no signivicant differences in urinary RBP, NAG and protein levels before treatment among patient groups (P0.05); ②There were significant decreases in urinary RBP and NAG following glucocorticoid therapy in those response to glucocorticoid (P0.01); ③There were significant differeces in urinary protein, RBP and NAG among three groups of patients with primary nephrotic syndrome after treatment. Conclusion Determination of urinary RBP may predict the sensibility of the therapy in the adult patients with primary nephrotic syndrome and its diagnostic efficiency is better than urinary NAG.