Comparison of novomix30 and metformin in treatment of diabetes mellitus combined with osteoporosis

2018 
Objective To compare the effect of novomix30 and metformin in treatment of diabetes mellitus combined with osteoporosis. Methods 117 patients diagnosed as type 2 diabetes mellitus (T2DM) combined with osteoporosis were collected from Sep. 2013 to Apr. 2017 in our hospital. They were divided into two groups: metformin group (n=53) , and novomix group (n=64) according to different therapies. General information of the two groups were comparable. The patients of metformin group reveived calcium, alendronate and metformin. The patients of novomix group received calcium, alendronate and novomix. The lumbar bone mineral density (BMD) , greater trochanter BMD, femoral neck BMD, Ward triangle BMD, the serum levels of BGP, alkaline phosphatase (ALP) , β-cross-linked C-telopeptide of typeⅠcollagen (β-CTX) , 1, 25- (OH) 2D3, the levels of fasting plasma glucose (FPG) , 2h plasma glucose (2h PG) , HBA1c and adverse reactions were recorded during the treatment. Results The lumbar BMD, greater trochanter BMD, femoral neck BMD, Ward triangle BMD of novomix group were higher than those of metformin group after treatment (P 0.05) . The adverse reactions rate of metformin group and novomix group was 28.30% and 25.00% respectively, and there was no significant difference between the two groups (P>0.05) . Conclusion Novomix30 can significantly improve bone metabolism level for patients combined with T2DM and osteoporosis, maintain bone remodeling balance, reduce bone loss, and improve BMD, which is worthy to be promoted. Key words: Novomix; Metformin; Diabetes mellitus; Osteoporosis; Bone mineral density
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