Formulation and Evaluation of Tablet in Tablet of Magnesium Glycine Complex and Vitamin D3 Tablets

The present research work is design and evaluate tablet in tablet of Magnesium and Vitamin D3 tablets (250 mg/1200 IU). Vitamin D is important for bone structure. If there is too little Vitamin D available not enough calcium reaches the blood through the intestinal walls. Magnesium & vitamin D essential for bone synthesis otherwise intensify to Osteoporosis. Mg is also credited with stabilizing functions in bone building. If there is no stabilizing function of Mg during bone synthesis, this also decrease bone density. The term Osteoporosis already indicates a lack of calcium in the bones. Mg & vitamin D rich diet can help to bring calcium back to where it belongs. All the formulations were evaluated for physical characteristics, disintegration, in vitro disintegration study and stability. Following conclusions have been made from the present study. PREFORMULATION STUDIES: The pre-formulation study carried out that angle of repose, bulk density, tapped density, compressibility, Hausner ratio. The results were clearly shown. Manufacturing process is lengthy but in the formulated product shows greater stability with adding less overages. EVALUATION OF DESIGNED FORMULATIONS: Post formulation studies: Physical characterization of all the lubricated blends were carried out and found to have good flow properties. The physical characteristics of all the blended formulations were satisfactory. The tablets prepared with the plain polymer mixture combination were found to have desired limits of hardness and thickness and complies to weight variation and within the official limits of friability. The drug release for formulation F4 was found to be 91.34% at the end of 45 mins. The prepared tablets were evaluated for Weight variation, Hardness, Friability, Disintegration time, Drug content and The prepared tablets evaluated for Assay, weight variation, thickness and Disintegration time were found to be within the official limits. The in vitro disintegration studies were performed for all the IT and OT formulations. The in vitro dissolution tests. The results were clearly shown. Accelerated Stability studies were also done for optimized formulation F4, F5 and the results were found satisfactory. This research work proven formulation tablet in tablet F4 of shows good stability compared with other 4 formulation. CONCLUSION: The results Vitamin D3 tablet in tablets of evaluation of different batches were done. The HPLC assy study shows that there was drug content final tablet. The weight variation limited tablets was found maximum up to ± 1.2 % RSD. Hardness was found to be within 3.0 to 4.0 kg/cm2 which limit friability within 0.7% only. The evaluation results of F4 batches were found to be satisfactory within limit and the disintegration time (4min). the same ratio the formulation F4 gave 92.47% drug release at 45 mins time point. The drug Contents was found to be within limits nd all tablets were passing the dispersion test. Vitamin D3 tablet in tablets of optimized all batch were of satisfactory stability during 3 months of accelerated stability studies.