Effects of different medicament forms of Zhishi Xiaopi Pill recipe on functional dyspepsia

[Objective] To explore the clinical effect of three different medicament forms of Zhishi Xiaopi Pill(ZSXPP) recipe on functional dyspepsia(FD).[Methods] One hundred and ninety-nine FD patients were randomly divided into four groups.Three groups of them were respectively treated with three different medicament forms of ZSXPP,while the control was treated with cisapride.[Results] There was no difference of the total therapeutic effectiveness among these four groups.The tension of vagus nerve and the motilin level in plasma were significantly increased by the treatment of different medicament forms of ZSXPP.The impaired contraction function of low esophageal sphincter in some FD patients with obvious reflux symptoms was improved too.[Conclusion]All of three different medicament forms of ZSXPP recipe were as effective as cisapride on FD.The efficacy was partly due to the improvement of esophageal and gastric dynamics which was probably related to the increasing of the tension of vagus nerve and the plasma level of motilin.