Strategizing the Treatment Approach to Acute Myeloid Leukemia
2021
For decades acute myeloid leukemia, the primary acute leukemia affecting adults, had limited treatment
options. Since 2017, we have seen discovery and development in cytogenetic and molecular classification
of acute myeloid leukemia, improved understanding of cell signaling pathways, and development of new
treatment for acute myeloid leukemia. These new treatments include novel combinations of agents and
therapy targeting molecular alterations improving rates of remission and overall survival. Treatment
discovery provides therapeutic opportunity to older patients and populations previously excluded from
intense induction chemotherapy. In this review, we discuss the timing of first therapy, non-intense treatment
regimens achieving remission, and new targets for directed therapy. We reference key clinical trials to
expand our discussion of newly approved agents for acute myeloid leukemia. In this review, we highlight
the discovery of treatment strategies to improve patient outcomes and ongoing research in leukemia.
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