The clinical value of arylsulphatase estimation in urine

Abstract 1. (1) The activity of arylsulphatase was examined in about 400 pathological and normal urines. 2. (2) The urine of healthy subjects contained only small amounts of arylsulphatase. 3. (3) More than a thirty-fold increase of the arylsulphatase was found in the urine of patients with myeloid leukaemias. 4. (4) There was only a slight increase of the enzyme activity in cases of Hodgkin's disease. 5. (5) A very marked increase of arylsulphatase activity was found in the urine of neoplastic patients in general and in the urine from cases of disease of the genitourinary tract. 6. (6) A slight increase of the urinary arylsulphatase activity was noted in cases of heart diseases, liver diseases, gout and other diseases. 7. (7) It seems probable that the increased amount of arylsulphatase appearing in some pathological urines is an excretory product arising from a neoplasm or an inflamed organ. 8. (8) The diagnostic and prognostic value of arylsulphatase estimation in urine is discussed. 9. (9) Increased levels of arylsulphatase are found in the urine of patients after surgical operations.